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Antioxidative metabolites synthesized by marine pigmented vibrio sp. and its protection on oxidative deterioration of membrane lipids

DRS at CSIR-National Institute of Oceanography

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Title Antioxidative metabolites synthesized by marine pigmented vibrio sp. and its protection on oxidative deterioration of membrane lipids
 
Creator Pawar, R.T.
Mohandass, C.
Dastager, S.G.
Kolekar, Y.M.
Malwankar, R.
 
Subject MICROBIOLOGY::General
MICROBIOLOGY::Physiology, biochemistry, biophysics
AQUATIC ECOLOGY, PRODUCTIVITY::Environmental effects
AQUATIC RESOURCES::Natural products
 
Description Bacterial strain Vibrio sp. (PIGB 184) isolated from water samples of the Arabian Sea and identified through 16S rRNA demonstrated the production of pigmentary antioxidants with higher ABTS activities 90.9?0.42 % in comparison with the standard commercial pigmented antioxidant, quercetin 88.8?1.4%. Antioxidative metabolites of this strain substantially inhibit the lipid peroxidation (LPO) reactions tested in sheep liver and brain. The antioxidant compounds produced by the Vibrio sp. (PIGB 184), analysed by GC-MS, reveals that it is composed mostly of phenol, 2,4-bis(1,1-dimethylethyl) and pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(2-methylpropyl). The interrelationship assessed between LPO and the phenolic compounds showed significant correlation with anti-LPO properties (R2=0.9698 to 0.9861). These compounds are responsible for obstruction of harmful radical associated biochemical reactions in biological systems. Pigmented metabolites also tested for attributive biological properties against pathogenic bacteria showed prominent inhibition towards Gram-positive organisms (31.25 to 62.5 mu g ml-1). From this study, it may be suggested that the marine bacterium PIGB 184 could be used as a potential bio-resource for antioxidants and needs to be worked out for mass production
 
Date 2016-07-11T09:17:33Z
2016-07-11T09:17:33Z
2016
 
Type Journal Article
 
Identifier Applied Biochemistry and Biotechnology, vol.179(1); 2016; 155-167
yes
http://drs.nio.org/drs/handle/2264/4990
 
Language en
 
Relation Appl_Biochem_Biotechnol_179_155.jpg
 
Rights An edited version of this paper was published by Springer. This paper is for R & D purpose and Copyright [2016] Springer
 
Publisher Springer