Antibacterial activity of marine bacillus substances against V. cholerae and S. aureus and in vivo evaluation using embryonic zebrafish test system
DRS at CSIR-National Institute of Oceanography
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Title |
Antibacterial activity of marine bacillus substances against V. cholerae and S. aureus and in vivo evaluation using embryonic zebrafish test system
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Creator |
Ravindran, C.
Varatharajan, G.R. Rajasabapathy, R. Sreepada, R.A. |
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Subject |
Microbiology::Physiology, biochemistry, biophysics
Microbiology::General Aquatic resources::Natural products Aquatic Products::Non-edible products |
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Description |
Cell free extracts of Bacillus subtilis subsp. spizizenii and B. thuringiensis isolated from hydrothermal vent region of Azorean Island Faial, North Atlantic Ocean showed antagonistic against V. cholera serogroup 01 and Staphylococcus aureus, respectively. The in vitro inhibitions of infectious pathogens by both B. subtilis subsp. spizizenii and B. thuringiensis was concentration dependent. The result of sensitivity to protease test showed considerable reduction of antibacterial activity for both Bacillus strains, indicating the proteinaceous nature of the antibacterial substances. Further, our results on antibacterial substance of heat resistant, proteinaceous nature and bacteriostatic mode of action was evaluated for the toxicity studies using zebrafish animal model, an alternative to the use of antibiotics test against infectious diseases. Bacillus antibacterial extracts showed no toxic effects with the Staphylococcus aureus-zebrafish embryo infection studies
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Date |
2016-10-13T12:29:55Z
2016-10-13T12:29:55Z 2016 |
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Type |
Journal Article
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Identifier |
Indian Journal of Pharmaceutical sciences, vol.78(3); 2016; 417-422
http://drs.nio.org/drs/handle/2264/5025 |
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Language |
en
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Rights |
Copyright [2016]. All efforts have been made to respect the copyright to the best of our knowledge. Inadvertent omissions, if brought to our notice, stand for correction and withdrawal of document from this repository.
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Publisher |
Indian Pharmaceutical Association
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