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Diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea

DRS at CSIR-National Institute of Oceanography

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Title Diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea
 
Creator Anas, A.
Nilayangod, C.
Jasmin, C.
Vinothkumar, S.
Parameswaran, P.S.
Nair, S.
 
Subject Microbiology::General
Geology and geophysics::Sediments and sedimentation
Aquatic resources::Natural products
 
Description Marine sediments accommodate plethora of diverse microorganisms with varying ecological functions. In the present study, we isolated bacteria from surficial sediments of south east Arabian Sea (AS) and evaluated their bioactive potentials. A total of 131 isolates belonging to the phylum: gama-Proteobacteria (63%), Bacillales (34%) and Micrococcaceae (3%) were isolated. Among these, about 40% of the isolates showed the presence of secondary metabolite biosynthetic genes such as PKS or NRPS or both. Organic extracts of nearly 50% of these organisms were cytotoxic to human breast cancer MCF-7 cells and were bactericidal to human pathogens, Escherichia coli and Pseudomonas sp., while 20-30% of them were bactericidal to Vibrio sp. and Staphylococcus sp. too. In all, 8 isolates, belonging to Pseudomonas spp., Bacillus sp. and/or Lysinibacillus sp. displayed high level of bactericidal/cytotoxic properties. The study proposes AS sediment as a rich source for microorganisms with prospective bioactive molecules
 
Date 2016-12-02T11:57:56Z
2016-12-02T11:57:56Z
2016
 
Type Journal Article
 
Identifier 3 Biotech, vol.6; 2016; no.238 doi. 10.1007/s13205-016-0556-x
http://drs.nio.org/drs/handle/2264/5057
 
Language en
 
Rights This is an open access article under the terms of the Creative Commons Attribution 4.0 International License ? Author(s) 2016.
 
Publisher Springer