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Evaluation of antioxidant and cytotoxic properties of Cynobacteria, Limnothrix sp. and Leptolyngbya sp. from Arabian sea

DRS at CSIR-National Institute of Oceanography

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Title Evaluation of antioxidant and cytotoxic properties of Cynobacteria, Limnothrix sp. and Leptolyngbya sp. from Arabian sea
 
Creator Anas, A.
Vinothkumar, S.
Gupta, S.
Jasmin, C.
Joseph, V.
Parameswaran, P.S.
Nair, S.
 
Subject Microbiology::Physiology, biochemistry, biophysics
Microbiology::General
 
Description The hexane fractions of the marine cyanobacteria: Leptolyngbya sp. and Limnothrix sp., collected from Arabian Sea were found to display promising antioxidant properties than their ethyl acetate fraction during radical scavenging ABTS/DPPH assays (IC50=30/330 and 60/260 ?g ml-1 respectively). Phytochemical analyses of the fractions indicated presence of carbohydrates, flavanoids and steroids in both organisms. The hexane fraction of Limnothrix sp. exhibited higher UV-Vis (300-450 nm) absorption, indicating presence of aromatic antioxidant compounds like flavanoids. This fraction was relatively non-toxic towards mouse fibroblast 3T3 cells (IC50 400 ?g ml-1) and in fact, protected live cells from UV induced intracellular reactive oxygen species (ROS) stress. On the contrary, the hexane fraction of Leptolyngbya sp. had lower UV-Vis absorption, richer in alkaloids and also more cytotoxic (IC50 200 ?g ml-1) towards the mouse fibroblast 3T3 cells. In short the hexane fraction of Limnothrix sp. is a safe antioxidant additive for food and healthcare products. On the other hand, the hexane fraction of Leptolyngbya sp. is rich in alkaloids and was cytotoxic, with potential application in cancer therapy
 
Date 2017-02-14T12:02:48Z
2017-02-14T12:02:48Z
2016
 
Type Journal Article
 
Identifier Journal of Microbiology, Biotechnology and Food Sciences, vol.6(3); 2016; 956-960
http://drs.nio.org/drs/handle/2264/5071
 
Language en
 
Rights Copyright [2016]. All efforts have been made to respect the copyright to the best of our knowledge. Inadvertent omissions, if brought to our notice, stand for correction and withdrawal of document from this repository.
 
Publisher Faculty of Biotechnology and Food Sciences