Record Details

TNF-a and IL-6 inhibitory effects of cyclic dipeptides isolated from marine bacteria Streptomyces sp.

DRS at CSIR-National Institute of Oceanography

View Archive Info
 
 
Field Value
 
Title TNF-a and IL-6 inhibitory effects of cyclic dipeptides isolated from marine bacteria Streptomyces sp.
 
Creator Nalli, Y.
Gupta, S.
Khajuria, V.
Singh, V.P.
Sajgotra, M.
Ahmed, Z.
Thakur, N.L.
Ali, A.
 
Subject Microbiology
Chemistry and biogeochemistry
Aquatic ecology, productivity
 
Description Inflammation is mediated by a variety of soluble factors, including a group of secreted polypeptides known as cytokines. The anti-inflammatory cytokines are a series of immune regulatory molecules that control the pro inflammatory cytokine response. Cytokines act in concert with specific cytokine inhibitors and soluble cytokine receptors to regulate the human immune response. The aim of the present study is to probe the anti-inflammatory potential of the crude extract and the bioactive metabolite isolated from marine bacteria Streptomyces sp. on key inflammatory mediators like tumor necrosis factor-a and interleukin-6. Here, we isolated ten known pyrazine-1,4-dione substituted cyclic dipeptide by semi-preparative HPLC and studied their anti-inflammatory activities against tumor necrosis factor-a and interleukin-6. Compound 3, 4, 5, 7 and 8 showed good inhibition of the both the cytokines in lipopolysaccharide-stimulated macrophages. The study reveal that compound 7 was to be specific inhibitor for tumor necrosis factor-a which efficiently inhibited tumor necrosis factor-a release in a dose-dependent manner and decreased lipopolysaccharide induced tumor necrosis factor-a production in human peripheral blood mononuclear cells in both the in vitro and in vivo experiments.
 
Date 2017-03-01T09:06:17Z
2017-03-01T09:06:17Z
2017
 
Type Journal Article
 
Identifier Medicinal Chemistry Research, vol.26(1); 2017; 93-100
http://drs.nio.org/drs/handle/2264/5081
 
Language en
 
Rights An edited version of this paper was published by Springer. This paper is for R & D purpose and Copyright [2016] Springer.
 
Publisher Springer and Business Media