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Antidiabetic and anti-inflammatory potential of sulphated polygalactans from red seaweeds Kappaphycus alvarezii and Gracilaria opuntia

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Relation http://eprints.cmfri.org.in/5782/
http://www.tandfonline.com/doi/abs/10.1080/10942912.2016.1209216?journalCode=ljfp20
 
Title Antidiabetic and anti-inflammatory potential of sulphated
polygalactans from red seaweeds Kappaphycus alvarezii and
Gracilaria opuntia
 
Creator Makkar, Fasina
Chakraborty, Kajal
 
Subject Bioactive compound
Biochemistry
Seaweed
 
Description Antidiabetic and anti-inflammatory potential of sulphated polygalactans
isolated from the red seaweeds Kappaphycus alvarezii and Gracilaria opuntia
were acquired by employing different in vitro systems. The sulphated
galactopyran motif derived from G. opuntia possessed significant antidiabetic
properties as identified by α-amylase (IC50 0.04 mg/mL), α-glucosidase
(IC50 0.09 mg/mL) and dipeptidyl peptidase-4 (DPP-4, IC50 0.09 mg/mL)
inhibitory activities. Based on the detailed nuclear magnetic resonance
spectroscopy experiments the sulphated galactopyran motif of G. opuntia
was designated as →3)-4-O-sulfonato-(6-O-acetyl)-β-D-galactopyranosyl-
(1→4)-3,6-anhydro-(2-O-sulfonato)-α-D-galactopyranosyl-(1→3)-4-O-sulfonato-(
6-O-acetyl)-β-D-xylosyl-(1→3)-4-O-sulfonato-(6-O-acetyl)-β-D-galactopyranosyl-(
1→4)-3,6-anhydro-(2-O-sulfonato)-α-D-galactopyranan, while the
one from K. alvarezii was demonstrated to be →4)-4-O-sulfonato-(2-Omethyl)-
β-D-galactopyranosyl-(1→4)-3,6-anhydro-(2-O-methyl)-α-D-galactopyranan.
The sulphated galactans from G. opuntia showed greater antiinflammatory
inhibitory activities as determined by cyclooxygenase-1
(COX-1, IC50 0.01 mg/mL), cyclooxygenase-2 (COX-2, IC50 0.03 mg/mL),
and 5-lipoxygenase inhibitory activities (5-LOX, IC50 0.24 mg/mL). This
study revealed that the sulfated polygalactan enriched concentrate from
G. opuntia can be used as potential therapeutic candidate to suppress the
hyperglycemic response in diabetic conditions and inflammatory activity.
They can be used to develop functional food ingredient in nutraceutical
products.
 
Publisher Taylor and Francis Online
 
Date 2017
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/5782/1/Antidiabetic%20and%20anti%20inflammatory%20potential%20_International%20Journal%20of%20Food%20Properties_2017_Kajal%20Chakraborty.pdf
Makkar, Fasina and Chakraborty, Kajal (2017) Antidiabetic and anti-inflammatory potential of sulphated polygalactans from red seaweeds Kappaphycus alvarezii and Gracilaria opuntia. International Journal of Food Properties, 20 (6). pp. 1326-1337.