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Anti-diabetic and anti-inflammatory activities of commonly available cephalopods

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Relation http://eprints.cmfri.org.in/11726/
http://www.tandfonline.com/doi/abs/10.1080/10942912.2016.1217008?src=recsys&journalCode=ljfp20
 
Title Anti-diabetic and anti-inflammatory activities of commonly
available cephalopods
 
Creator Chakraborty, Kajal
Joy, Minju
 
Subject Bioactive compound
Biochemistry
Cephalopods
 
Description Anti-diabetic and anti-inflammatory activities of ethyl acetate-methanol
extracts of cephalopods namely, Amphioctopus marginatus, Urothethis
duvauceli, Sepia pharaonis, Sepiella inermis, and Cistopus indicus were
evaluated. The ethyl acetate-methanol extracts of C. indicus exhibited significantly
greater (p < 0.05) cyclooxygenase inhibition activities (IC90 ~ 1
mg/mL, respectively) compared to other cephalopod species. Likewise, C.
indicus displayed greater 5-lipoxygenase inhibitory activity (IC90 1.69 mg/
mL) compared to the other cephalopod species (IC90 > 2 mg/mL) considered
in the present study. The solvent extracts derived from the members
of the order Octopoda demonstrated fairly good α-amylase inhibitory activity
(IC90 ≤ 2.5 mg/mL). Dipeptidyl peptidase-4 inhibitory activity of the
ethyl acetate-methanol extract of C. indicus was found to be significantly
greater (IC50 2.51 mg/mL) than other species of cephalopods (IC50 3.4–5.4
mg/mL; p < 0.05). The labeling of protons associated with different magnetic
environments of the functional groups exhibited in the ethyl acetatemethanol
extracts were analyzed by proton nuclear magnetic resonance
spectroscopy that supported the in vitro anti-diabetic and anti-inflammatory
results. The ethyl acetate-methanol extract of C. indicus and S. inermis
displayed greater proton integrals (ΣH) of highly electronegative moieties
appeared in the low-field region in the proton nuclear magnetic resonance
spectroscopy spectra (C. indicus ΣHδ3.5–4.5 5.34, ΣHδ4.5–6.5 6.41; S. inermis
ΣHδ3.5–4.5 6.52, and ΣHδ4.5–6.5 15.39) than other cephalopod species.
A significant co-linearity was found between the electronegative groups
present in the downfield position of nuclear magnetic resonance spectroscopy
spectra vis-à-vis anti-diabetic and anti-inflammatory activities.
 
Publisher Taylor and Francis Online
 
Date 2017
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/11726/1/International%20Journal%20of%20Food%20Properties_Anti%20diabetic%20and%20anti%20inflammatory%20activities%20of%20commonly%20available%20cephalopods_Kajal%20Chakraborty_2017.pdf
Chakraborty, Kajal and Joy, Minju (2017) Anti-diabetic and anti-inflammatory activities of commonly available cephalopods. International Journal of Food Properties, 20 (7). pp. 1655-1665.