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Study Of Rpb4, A Component Of RNA Polymerase II As A Coordinator Of Transcription Initiation And Elongation In S. Cerevisiae

Electronic Theses of Indian Institute of Science

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Title Study Of Rpb4, A Component Of RNA Polymerase II As A Coordinator Of Transcription Initiation And Elongation In S. Cerevisiae
 
Creator Deshpande, Swati
 
Subject Yeast Genetics
RNA Polymerase
Saccharomyces cerevisiae
RNA Transcription
Rpb4
RNA Polymerase II
Rpb1 Protein-C-Terminal Domain Phosphorylation
Genetic Transcription
Rpb1-CTD
RNA Pol II
Biochemical Genetics
 
Description RNA polymerase II (Pol II) is the enzyme responsible for the synthesis of all mRNAs in eukaryotic cells. As the central component of the eukaryotic transcription machinery, Pol II is the final target of transcription regulatory pathways. While the role for different Pol II associated proteins, co-activators and general transcription factors (GTFs) in regulation of transcription in response to different stimuli is well studied, a similar role for some subunits of the core Pol II is only now being recognized. The studies reported in this thesis address the role of the fourth largest subunit of Pol II, Rpb4, in transcription and stress response using Saccharomyces cerevisiae as the model system. Rpb4 is closely associated with another smaller subunit, Rpb7 and forms a dissociable complex (Edwards et al. 1991). The rpb4 null mutant is viable but is unable to survive at extreme temperatures (>34ºC and
 
Contributor Sadhale, Parag
Vijayaraghavan, Usha
 
Date 2017-05-24T15:37:05Z
2017-05-24T15:37:05Z
2017-05-24
2013
 
Type Thesis
 
Identifier http://etd.iisc.ernet.in/handle/2005/2624
http://etd.ncsi.iisc.ernet.in/abstracts/3388/G26007-Abs.pdf
 
Language en_US
 
Relation G26007