Record Details


Field	Value

Title	Attenuation of virulence and changes in morphology in Candida albicans by disruption of the N-acetylglucosamine catabolic pathway

Creator	Singh, Praveen Ghosh, Sharmistha Datta, Asis

Subject	Candida albicans N-Acetylglucosamine Catabolic Pathway virulence and morphogenesis

Description	A Candida albicans mutant with mutations in the N-acetylglucosamine (GlcNAc) catabolic pathway gene cluster, including the GlcNAc-6-phosphate deacetylase (DAC1), glucosamine-6-phosphate deaminase (NAG1), and GlcNAc kinase (HXK1) genes, was not able to grow on amino sugars, exhibited highly attenuated virulence in a murine systemic candidiasis model, and was less adherent to human buccal epithelial cells in vitro. No germ tubes were formed by the mutant after induction with GlcNAc, but the mutant exhibited hyperfilamen- tation under stress-induced filamentation conditions. In addition, the GlcNAc catabolic pathway played a vital role in determining the colony phenotype. Our results imply that this pathway is very important because of its diverse links with pathways involved in virulence and morphogenesis of the organism. This work was supported by a grant from the Department of Biotechnology, India

Date	2013-10-09T06:39:34Z 2013-10-09T06:39:34Z 2001

Type	Article

Identifier	Infection and Immunity, 69(12): 7898-7903 http://hdl.handle.net/123456789/18

Language	en

Publisher	American Society for Microbiology

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