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Type II Phosphatidylinositol 4-kinase(s) in Cell signaling Cascades

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Title Type II Phosphatidylinositol 4-kinase(s) in Cell signaling Cascades
 
Creator Sinha, Ranjeet Kumar
Subrahmanyam, Gosukonda
 
Subject Lipid kinases
Cell signaling
Cytoskeleton
Cell adhesion
Microbial pathogenicity
 
Description 289-294
Phosphorylated derivatives of phosphatidylinositol (PtdIns) are key components of many signaling cascades. Many isoforms of PtdIns kinases, PtdIns phosphate kinases and phosphatases use these lipids in amazing networks of signaling cascades that are yet to be understood fully. PtdIns 4-kinase(s) phosphorylates PtdIns at the 4th –OH position of inositol head group and are classified in to type II and III PtdIns 4-kinases. While type III PtdIns 4-kinases are implicated in vesicular trafficking, type II PtdIns 4-kinases are suggested to play a role in cell signaling, cytoskeletal rearrangements, cell motility and in microbial pathogenicity. This paper reviews the role of type II PtdIns 4-kinases in cell signaling cascades in health and disease.
 
Date 2008-02-22T09:04:38Z
2008-02-22T09:04:38Z
2007-10
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/128
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.44(5) [October 2007]