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Antiphospholipid antibodies in young myocardial infarction patients

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Field Value
 
Title Antiphospholipid antibodies in young myocardial infarction patients
 
Creator Mishra, Mahendra N
Kalra, Ravi
Gupta, Mahendra K
 
Subject Myocardial infarction
Anticardiolipin antibodies
Lupus anticoagulants
 
Description 481-484
Myocardial infarction (MI) is a multi-factorial disease which claims many young lives. There are very few Indian studies that have investigated antiphospholipid antibodies (APLs) in MI patients. APLs have been implicated in arterial thrombosis including premature coronary artery and cerebrovascular thrombosis. In the present study, the prevalence of two clinically significant APLs — anticardiolipin antibody (ACA) and lupus anticoagulants (LA) in young MI patients was studied and compared with age- and sex-matched controls. Fifty healthy blood donors and 40 young MI patients (less than 45 yrs) diagnosed according to the American Heart Association guidelines were recruited for the study. The criteria for diagnosis were presence of atleast two of three classical findings including: clinical symptoms, diagnostic ECG, and presence of one or more cardiac biomarkers out of raised CK-MB isoform and T-troponin on serial measurement. LA and ACA were tested by lupus-sensitive activated partial thromboplastin time (aPTT) and ELISA respectively. Elevation of ACA was observed in 9 patients, while 6 were positive for LA. ACA of IgG isotype was detected in 8 patients. One patient had LA and raised ACA of IgG and IgM isotypes. Antiphospholipid antibodies were found to be significantly associated with MI in young patients, when considered together (p
 
Date 2008-02-25T11:18:39Z
2008-02-25T11:18:39Z
2007-12
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/151
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.44(6) [December 2007]