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Synthesis and bronchodilatory activity of new 4-aryl-3,5-bis(2-chlorophenyl)- carbamoyl-2,6-dimethyl-1,4- dihydropyridines & their 1-substituted analogues

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Title Synthesis and bronchodilatory activity of new 4-aryl-3,5-bis(2-chlorophenyl)- carbamoyl-2,6-dimethyl-1,4- dihydropyridines & their 1-substituted analogues
 
Creator Suresh, T
Swamy, S K
Reddy, V M
 
Subject N-(2-Chlorophenyl)acetoacetamide
1,4-dihydropyridine
potassium tert-butoxide
trimethyl silyl iodide
1-n-butyl-3-methylimidazolium tetrafluoroborate
bronchodilatory activity
 
Description 115-121
Thirty five different 4-aryl-1-substituted 2,6-dimethyl-3, 5-bis-N-[(substituted) carbamoyl] 1,4-dihydropyridines have been prepared from a three component condensation reaction of N-(2-chlorophenyl)-acetoacetamide; an aromatic aldehyde and a primary amine under four different experimental conditions. Except for conventional, all the experimental conditions are simple, eco-friendly, economical, and the reactions are rapid and high yielding. All the compounds have been purified and characterized by their spectral and elemental analysis data. The methods employed have been compared in terms of yields, cost and simplicity. All the compounds have been tested for their acute toxicity, gross behavioural studies and screened for their bronchodilatory activity by standard methods.
 
Date 2008-03-18T10:48:57Z
2008-03-18T10:48:57Z
2007-01
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/390
 
Language en_US
 
Relation Int.Cl.⁸ C07D
 
Publisher CSIR
 
Source IJC-B 46B(1) January 2007