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Synthesis and study of some compounds containing oxazolone ring, showing biological activity

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Title Synthesis and study of some compounds containing oxazolone ring, showing biological activity
 
Creator Tandel, R C
Mammen, Denni
 
Subject Phenyloxazol-5-one
Benzoyl glycine
Antibacterial activity
Antifungal activity
Seed germination
Liquid crystalline property
 
Description 932-937
Synthesis of the oxazolone ring has been performed by the condensation of 4-substituted alkoxy benzoyl glycine with appropriate 4-substituted alkoxy benzaldehyde, in the presence of acetic anhydride and anhydrous sodium acetate. The antibacterial activity has been checked against Micrococcus luteus and Escherichia coli and antifungal activity against Alternaria alternate and Phoma multirostata for all the compounds. The cytotoxicity has been checked against the monocots barley seeds; Hordeum vulgare L and dicots moong seeds; Phaseolus aureus. The compounds having electron releasing group exhibit antibacterial activity. Compounds with nitro group cause total inhibition of seed germination, exhibiting cytotoxic behaviour. The structures of the synthesized compounds have been characterized by elemental analysis and spectral data and the purity of the compounds has been checked by TLC method.
 
Date 2008-07-25T09:50:06Z
2008-07-25T09:50:06Z
2008-06
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/1744
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.47B(6) [June 2008]