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Host genes that affect progression of AIDS/HIV in India and novel gene therapeutic approaches against HIV

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Title Host genes that affect progression of AIDS/HIV in India and novel gene therapeutic approaches against HIV
 
Creator Sood, Vikas
Rathore, Anurag
Husain, Sajid
Khan, Sohrab
Patra, Shruti
Shankar, Vijay
Kumar, Harsh
Rani, Neha
Bano, Aalia S
Neogi, Ujjwal
Ramachandran, V G
Banerjea, Akhil C
 
Subject HIV-1
CCR5
Polymorphisms
Chemokine receptors
DNA-enzyme
Ribozyme
siRNA
Lentiviral vectors
 
Description 141-148
A multitude of host and viral factors play critical role in susceptibility to HIV-1 infection and its subsequent progression
to AIDS. Various host factors involved in HIV-1 infection include the chemokine receptors CCR5, CX3CR1, their ligands,
RANTES, SDF-1 and cytokines like IL-10, IL-4, among others. The CCR5Δ32 allele is the most important genetic factor
known to confer resistance to HIV-1 infection. However, other mutations in CCR5, CX3CR1 and SDF-1 have also been
identified in Indian population. Polymorphisms in DC-SIGN, MHC class-I and II molecules are also known to affect HIV-1
progression. These polymorphisms can be utilized as genetic markers for evaluating disease progression and developing
effective therapeutics. The review also describes the development of anti-viral therapy, involving the use of catalytic nucleic
acids like DNA-enzymes and ribozymes and the expression of ribozymes and si-RNA using lentiviral vectors for stem cell
based anti-HIV therapy.
 
Date 2008-08-29T10:39:24Z
2008-08-29T10:39:24Z
2008-06
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/1925
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.45(3) [June 2008]