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Effects of soluble antigen-induced immune cell activation on steroidogenesis in murine lymphoid organ

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Title Effects of soluble antigen-induced immune cell activation on steroidogenesis in murine lymphoid organ
 
Creator Mukhopadhyay, Rupanjan
Bishayi, Biswadev
 
Subject Steroidogenic enzyme
Soluble antigen
Lymphoid organ
Corticosterone
Cytokine
 
Description 250-255
The effect of soluble antigenic (bovine serum albumin, BSA) stimulation to induce steroidogenesis in murine lymphoid
organs with concomitant changes in proinflammatory or inflammatory cytokine levels and its implication in the alteration of
T-cell response was studied in the mice. Male Swiss albino mice (6-8 weeks old) with average body weight (20 ± 4 g) were
randomly assigned to 3 groups and injected with BSA in presence and absence of Freund’s complete or incomplete
adjuvant, whereas the control group received only saline. After 3 weeks, animals were sacrificed, and serums as well as
lymphoid organs were collected. From the lymphoid tissue homogenate, the activities of steroidogenic enzymes and
corticosterone and cytokine levels of the serum were estimated. Steroidogenic enzyme activities in murine lymphoid organs,
as well as the pro-inflammatory and inflammatory cytokines levels in serum increased after Freund’s complete adjuvantemulsified
BSA administration, as compared to control. The serum corticosterone and serum cytokine profile were also
elevated. Results suggested that soluble protein antigen (BSA) administration stimulated steroidogenesis in murine
lymphoid tissues and rise in the pro-inflammatory or inflammatory cytokine levels might indicate monocyte recruitment as
well as TH₁ activation.
 
Date 2008-09-01T11:02:49Z
2008-09-01T11:02:49Z
2008-08
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/1940
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.45(4) [August 2008]