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Design and syntheses of some new diphenylaminoisoxazolines as potent anti-inflammatory agent

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Title Design and syntheses of some new diphenylaminoisoxazolines as potent anti-inflammatory agent
 
Creator Dravyakar, B R
Kawade, D P
Khedekar, P B
Bhusari, K P
 
Subject Quantitative structure–activity relationships
Nonsteroidal anti-inflammatory drugs
Isoxazoline derivatives
 
Description 1559-1567
In the present investigation, a QSAR study is performed on twenty diphenylamino-2-isoxazoline derivatives using modified version of Allinger MM2 force field in Chem3D ultra structural descriptors. The relationship between anti-inflammatory activity and various descriptors is established by stepwise multiple regression analysis. The analyses have produced well predictive and statistically significant QSAR models which are further cross validated. This study helps to design some expectedly potent compounds and synthesized, accordingly. These compounds are auxiliary screened spectroscopically and tested for anti-inflammatory activity. All compounds have showed better activity when compared with ibuprofen as standard. These compounds are further subjected to ulceration studies showing good results with almost no ulcerogenic activity.
 
Date 2008-10-22T07:37:27Z
2008-10-22T07:37:27Z
2008-10
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/2260
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.47B(10) [October 2008]