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p-Toluenesulfonic acid catalyzed rapid and efficient protocol for one-pot synthesis of α-amino nitriles

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Title p-Toluenesulfonic acid catalyzed rapid and efficient protocol for one-pot synthesis of α-amino nitriles
 
Creator Reddy, Ch Sanjeeva
Raghu, M
 
Subject p-TsOH
α-amino nitriles
One-pot three-component condensation
Carbonyl compounds
Amines
Trimethylsilyl cyanide
 
Description 1572-1577
A simple, rapid and efficient practical method for one-pot synthesis of α-amino nitriles has been achieved by a three-component condensation of carbonyl compounds, amines and trimethylsilyl cyanide in the presence of p-toluenesulfonic acid
(p-TsOH) as a catalyst at ambient temperature. Operational simplicity, economic consideration, high yield, short reaction time and low toxicity are the key features associated with this protocol.
 
Date 2008-10-22T07:38:13Z
2008-10-22T07:38:13Z
2008-10
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/2263
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.47B(10) [October 2008]