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Synthesis and β-adrenergic blocking activity of naphthyloxypropylamines

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Title Synthesis and β-adrenergic blocking activity of naphthyloxypropylamines
 
Creator Vattipalli, Ramya
Shirodkar, Prabhakar Y
Somani, Rakesh R
Kadam, Vilasrao J
 
Subject Synthesis
β-adrenergic blockers
Aryloxypropanolamines
 
Description 1587-1590
A series of 1-isopropylamino-3-(3'-substituted-2'-naphthyloxy)-2-propanols have been synthesized and their structures have been confirmed by spectral analysis. All the derivatives have shown β-adrenergic blocking effect when tested on perfused frog heart. Compound 4e exhibited 100% blockade of adrenaline response.
 
Date 2008-10-22T07:39:00Z
2008-10-22T07:39:00Z
2008-10
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/2266
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.47B(10) [October 2008]