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Facile syntheses of 4-hydroxy-7-methyl-1-indanone, isolated from cyanobacterium Nostoc commune
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View Archive Info| Field | Value | |
| Title |
Facile syntheses of 4-hydroxy-7-methyl-1-indanone, isolated from cyanobacterium Nostoc commune
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| Creator |
Kamat, Shrivallabh P
Menezes, Jose C Siddhaye, Bhushan M Paknikar, Shashikumar K |
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| Description |
1597-1599
Two different high yielding synthetic routes both starting with 6-methylcoumarin 2 have been described to prepare 4-hydroxy-7-methyl-1-indanone 1, a constituent of cyanobacterium Nostoc commune having antibacterial activity. In the first route, methylative lactone ring opening of the coumarin 2 followed by catalytic hydrogenation of the cinnamyl double bond and subsequent PPA cyclization gives the methyl ether 5 of 1 which on demethylation gives 1 in excellent yield. Alternatively, catalytic hydrogenation of 2 followed by fusion with anhydrous AlCl₃ gives high yield of 1 in just two steps. |
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| Date |
2008-10-22T07:36:36Z
2008-10-22T07:36:36Z 2008-10 |
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| Type |
Article
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| Identifier |
0376-4699
http://hdl.handle.net/123456789/2256 |
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| Language |
en_US
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| Publisher |
CSIR
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| Source |
IJCB Vol.47B(10) [October 2008]
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