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Process optimization for citric acid production from raw glycerol using response surface methodology

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Title Process optimization for citric acid production from raw glycerol using response surface methodology
 
Creator Kumari, K Sita
Babu, I Sarat
Rao, G H
 
Subject Citric acid
Central composite design
Raw glycerol
Response surface methodology
Yarrowia lipolytica
 
Description 496-501
Statistical experimental design was applied for the optimization of medium constituents for citric acid production by Yarrowia lipolytica NCIM 3589 in submerged fermentation using raw glycerol as the carbon source. Response surface methodology (RSM) involving central composite design (CCD) was adopted to evaluate the amount of citric acid produced by most important factors, such as carbon concentration, nitrogen concentration, and salt solution concentration. A second order polynomial regression model was fitted and was found adequate with R² of 0.9485. The optimum conditions were found to be carbon concentration 38.77 g/L, nitrogen concentration 0.401 g/L, and salt solution concentration 12.3 % (v/v). Citric acid production at these optimum conditions was 13.41 g/L.
 
Date 2008-11-05T04:27:28Z
2008-11-05T04:27:28Z
2008-10
 
Type Article
 
Identifier 0972-5849
http://hdl.handle.net/123456789/2353
 
Language en_US
 
Publisher CSIR
 
Source IJBT Vol.7(4) [October 2008]