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Protective effect of taurine and quercetin against renal dysfunction associated with the combined use of gentamycin and diclofenac

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Title Protective effect of taurine and quercetin against renal dysfunction associated with the combined use of gentamycin and diclofenac
 
Creator Eldin, Adel A Kheir
Shaheen, Amira A.
Elgawad, Hanan M Abd
Shehata, Nagwa I
 
Subject Nephrotoxicity
Gentamycin
NSAIDs
Taurine
Quercetin
 
Description 332-340
The potential protective effects of taurine and quercetin against gentamycin (GM)/diclofenac (DC) combined
nephrotoxicity were investigated in rats. The results showed that administration of DC alone at an oral dose of 5 mg/kg
b.wt/day for 28 days had no significant effect on the measured parameters, except for marked increase in urinary uronic acid
excretion. Administration of GM alone at a dose of 100 mg/kg b.wt/day i.p. for 8 days resulted in obvious nephrotoxicity.
Combined GM-DC treatment led to the most pronounced nephrotoxicity, as indicated by greater elevations in serum urea,
creatinine and urinary N-acetyl-β-D-glucosaminidase (NAG), together with severe depression of renal cortical Na⁺, K⁺-
ATPase, compared to GM-treated group. Moreover, only combined treatment resulted in significant decrease in urinary
potassium and renal cortical glutathione peroxidase (GSHPx), together with an increase in renal cortical lipid peroxidation
products (LPOs). Co-administration of taurine or quercetin normalized creatinine clearance and ameliorated the elevations
in urinary proteins, uronic acids, NAG and renal cortical LPOs in GM/DC treated rats. The study justifies the use of taurine
and quercetin as renoprotective agents against the nephrotoxicity caused by GM/DC therapy.
 
Date 2008-11-06T04:12:13Z
2008-11-06T04:12:13Z
2008-10
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/2375
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.45(5) [October 2008]