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Suppressive effect of Strychnos nux-vomica on induction of ovalbumin-specific IgE antibody response in mice

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Title Suppressive effect of Strychnos nux-vomica on induction of ovalbumin-specific IgE antibody response in mice
 
Creator Duddukuri, Govinda Rao
Brahmam, A Naga
Rao, D N
 
Subject Strychnos nux-vomica
Immunomodulation
Immunosuppression
IgE antibody response
Passive cutaneous
 
Description 341-344
Strychnos nux-vomica Linn. (SNV; Loganiaceae), a medicinal
plant has been used as folk medicine for alleviating inflammation,
joint pains and allergic symptoms. In the present study, we
examined its possible immunomodulatory effect on induction of
ovalbumin (OVA)-specific IgE antibody response in a murine
model, as evaluated by passive cutaneous anaphylaxis (PCA). The
OVA-specific IgE antibody response was significantly suppressed
in BALB/c mice (H-2d), following intraperitoneal administration
of aqueous stem extract of the plant along with OVA.
Furthermore, the different doses of SNV extract were found to
significantly suppress the induction of OVA-specific IgE antibody
response. The anti-OVA IgE antibody response was suppressed in
different haplotypes of mice viz., C57BL/6 (H-2b) and SWR/J
(H-2q). However, preliminary findings revealed no significant
change in the total IgG antibody response against OVA, as
evaluated by ELISA. These results confirm the suppressive
activity of S. nux-vomica on allergen-specific IgE antibody
response and suggest its possible application in allergic
conditions.
 
Date 2008-11-06T04:13:00Z
2008-11-06T04:13:00Z
2008-10
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/2376
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.45(5) [October 2008]