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Kinetics and mechanism of Ru(III) catalyzed and uncatalyzed oxidation of atenolol by chloramine-T in perchloric acid medium

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Title Kinetics and mechanism of Ru(III) catalyzed and uncatalyzed oxidation of atenolol by chloramine-T in perchloric acid medium
 
Creator Suresha, N
 
Description 1649-1655
The kinetics and mechanism of chloramine-T (CAT)-oxidation of atenolol (ATN) in aqueous perchloric acid medium have been studied at 26 ± 0.1ºC in the presence and absence of Ru(III) catalyst. Under identical experimental conditions, the reaction shows a first-order dependence on [CAT]₀, a zero-order dependence on [ATN]₀ and an inverse fractional-order dependence on [H⁺] for both the Ru(III) catalyzed and uncatalyzed reactions. The order with respect to Ru(III) is unity. Variation of ionic strength and addition of p-toluenesulfonamide or chloride ion have no effect on the rate. Decrease in dielectric constant of the reaction medium decreases the rate constant in both cases. Activation parameters have been computed. The stoichiometry of the reaction is found to be 1:4 and the main oxidation products are identified as
4-acetamidobenzeneoxyacetic acid and isopropyl amine. Based on the kinetic data, the conjugate acid, CH₃C₆H₄SO₂NHCl, is assumed to be the reactive oxidizing species in both cases. The Ru(III) catalyzed reactions are 2-3 times faster than the uncatalyzed reactions. Mechanisms consistent with the observed rate laws have been proposed.
 
Date 2008-12-05T05:40:31Z
2008-12-05T05:40:31Z
2008-11
 
Type Article
 
Identifier 0376-4710
http://hdl.handle.net/123456789/2476
 
Language en_US
 
Relation Int. Cl. ⁸ : C07B33/00
 
Publisher CSIR
 
Source IJCA Vol.47A(11) [November 2008]