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Localization of Heme Biosynthesis Pathway Enzymes in Plasmodium falciparum

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Title Localization of Heme Biosynthesis Pathway Enzymes in Plasmodium falciparum
 
Creator Rao, Aditya
Yeleswarapu, Sri Jyothsna
Srinivasan, Rajgopal
Bulusu, Gopalakrishnan
 
Subject Plasmodium falciparum
Localization
Apicoplast
Mitochondrion
Heme biosynthesis
Heme pathway enzymes
 
Description 365-373
Protein trafficking in the malarial parasite Plasmodium falciparum is dictated by a complex life-cycle that involves a variety of intra-cellular and host cell destinations, such as the mitochondrion, apicoplast, rhoptries and micronemes. Of these, the apicoplast and mitochondrion are believed to account for more than 10% of this traffic. Studies have shown that mechanisms for mitochondrion and apicoplast targeting are distinct, despite their close physical proximity. The heme biosynthesis pathway spans both these organelles, making trafficking studies crucial for the spatial demarcation of the constituent interactions. This minireview highlights the challenges in identifying the possible sub-cellular destinations of the heme pathway enzymes using gleanings from literature survey as well as focussed bioinformatic analysis.
 
Date 2008-12-31T05:41:28Z
2008-12-31T05:41:28Z
2008-12
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/2702
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.45(6) [December 2008]