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Regioselective reaction: Synthesis of novel Mannich bases derived from 3-(4,6-disubstituted-2-thiomethylpyrimidyl)-4-amino-5-mercapto-1,2-4-triazoles and their antimicrobial properties

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Title Regioselective reaction: Synthesis of novel Mannich bases derived from 3-(4,6-disubstituted-2-thiomethylpyrimidyl)-4-amino-5-mercapto-1,2-4-triazoles and their antimicrobial properties
 
Creator Lingappa, B
Girisha, K S
Kalluraya, Balakrishna
Rai, N Satheesh
Kumari, Nalilu Suchetha
 
Subject 1,2,4-Triazoles
Pyrimidines
Schiff bases
Mannich bases
 
Description 1858-1864
A new series of 3-(4,6-disubstituted-2-thiomethylpyrimidyl)-4-amino-5-mercapto-1,2-4-triazoles have been synthesized. These triazoles on reaction with aldehydes in the presence of acid catalyst forms Schiff’s bases. These Schiff’s bases can exist both in the thiol as well as in the thione tautomeric form. However when these compounds are subjected to Mannich reaction, N-Mannich bases 7a-f are obtained rather than the S-Mannich bases. The structures of the new compounds have been confirmed by spectral and analytical data. Few of these Mannich bases have been evaluated for their possible antifungal and antibacterial activity. Most of the tested compounds show significant antifungal and antibacterial activity.
 
Date 2009-01-13T05:10:14Z
2009-01-13T05:10:14Z
2008-12
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/2746
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.47B(12) [December 2008]