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Tin(lV) catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions

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Title Tin(lV) catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions
 
Creator Rameshwar, N
Parthasarathy, T
Reddy, A Ram
 
Subject Biginelli reaction
Dihydropyrimidinones
Tin(IV) chloride
Solvent-free condition
 
Description 1871-1875
One pot condensation of ethyl acetoacetate or methyl acetoacetate with various para and ortho substituted aromatic aldehydes and urea or thiourea by tin(IV) chloride affords twenty-one different substituted 3,4–dihydropyrimidin-2-(1H)-ones. Tin(IV) chloride has emerged as a powerful catalyst for the preparation of 3,4–dihydropyrimidin-2-(1H)-ones under simple and mild conditions. It is compatible with a wide variety of substituents in the aromatic aldehyde. Substituents at para position in aldehyde are more effective than the substituents at ortho position. Both the β–ketoesters, and urea or thiourea are equally effective towards an efficient 3,4–dihydropyrimidin-2-(1H)-one synthesis.
 
Date 2009-01-13T05:28:13Z
2009-01-13T05:28:13Z
2008-12
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/2749
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.47B(12) [December 2008]