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Synthesis of some novel ethoxyphthalimide derivatives of pyrazolo[3,4-c]pyrazoles

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Title Synthesis of some novel ethoxyphthalimide derivatives of pyrazolo[3,4-c]pyrazoles
 
Creator Sharma, Chirag
Thadhaney, Bhawana
Pemawat, Gangotri
Talesara, G L
 
Subject Thiosemicarbazide
Isoniazid
Phthalimidoxyethyl bromide
Pyrazolo[3,4-c]pyrazoles
 
Description 1892-1897
The synthesis of 5-methyl-4-substituted benzylidene-2,4-dihydro-3H-pyrazol-3-one 3a-d is achieved by the condensation reaction of 5-methyl-2,4-dihydro-3H-pyrazol-3-one 1 with 4-substituted benzaldehydes 2a-d. Compound 1 is prepared by the cyclization reaction between ethylacetoacetate and hydrazine hydrate in absolute alcohol. Compounds 3a-d are converted into corresponding ethoxyphthalimide derivatives 5a-d by treatment with phthalimidoxyethyl bromide 4. 1-N-Ethoxyphthlimido-3-methyl-4-(4-substituted benzylidene)pyrazol-5-ones 5a-d are reacted with thiosemicarbazide/NaOH and isoniazid/AcONa/AcOH separately to yield 6-N-ethoxyphthalimido-4-methyl-3-(4-substituted phenyl)-2-thiocarbamoyl-3,3a-dihydro pyrazolo[3,4-c]pyrazoles 6a-d and 6-N-ethoxyphthalimido-2-isonicotinoyl-4-methyl-3-(4-substituted phenyl)-3,3a-dihydro pyrazolo[3,4-c]pyrazoles 7a-d respectively. Structures of the synthesized compounds have been elucidated by means of IR, 1H NMR and mass spectral data.
 
Date 2009-01-13T06:41:38Z
2009-01-13T06:41:38Z
2008-12
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/2754
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.47B(12) [December 2008]