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Synthesis of N-(substituted benzyl)-2-(3′,5′-dimethyl-4′-hydroxyphenyl) acetamides

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Title Synthesis of N-(substituted benzyl)-2-(3′,5′-dimethyl-4′-hydroxyphenyl) acetamides
 
Creator Raju, B China
 
Subject Acetamides
4-benzyloxy-3,5-dimethylphenylacetate
Substituted benzyl amines
Tetrahydroisoquinolines
 
Description 1903-1905
4-Benzyloxy-3,5-dimethylphenylacetate 1 reacts with substituted benzyl amines 2a-e affords N-substituted benzyl-2-(4′-benzyloxy-3′,5′-dimethylphenyl) acetamides 3a-e, which on debenzylation give N-substituted benzyl-2-(3′,5′-dimethyl-4′-hydroxy phenyl) acetamides 4a-e in very good yields which are important intermediates for the synthesis of 1,2,3,4-tetrahydroisoquinolines.
 
Date 2009-01-13T05:27:54Z
2009-01-13T05:27:54Z
2008-12
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/2748
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.47B(12) [December 2008]