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An investigation leading to preparation of tetrahydro-quinazoline derivatives involving ureidoalkylation and ⍺-amidoalkylation reactions

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Title An investigation leading to preparation of tetrahydro-quinazoline derivatives involving ureidoalkylation and ⍺-amidoalkylation reactions
 
Creator Pandey, V K
Mukesh
Kumar, Anilesh
Trivedi, Noopur
 
Subject Ureidoalkylation
Tetrahydroquinazolines
Spontaneous motor activity
 
Description 1910-1914
Reaction of an aldehyde with excess equivalent of urea in ethanol affords alkylideno/arylideno-bis-ureas 1 which on condensation with p-aminophenol in acidic medium cyclised to
4-aralkyl-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines 2. Reaction of 2 with arylamidoalcohols in concentrated H2SO4 results in 4-arylkyl-7-arylamido/imidoalkyl-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines 3. Compounds 3 have been evaluated for their effect on central nervous system (CNS) and cardiovascular system (CVS).
 
Date 2009-01-13T06:45:17Z
2009-01-13T06:45:17Z
2008-12
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/2755
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.47B(12) [December 2008]