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Voltammetric DNA biosensor for the study of mechanism of action of anticancer drug-adriamycin

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Title Voltammetric DNA biosensor for the study of mechanism of action of anticancer drug-adriamycin
 
Creator Tiwari, Sweety
Pitre, K S
 
Subject Modified electrode
Biosensor
Adriamycin
Anthracycline compound
 
Description 593-597
The interaction of anticancer drug adriamycin with DNA has been studied using voltammetric DNA biosensor. The binding mechanism of adriamycin was elucidated by using differential pulse voltammetry (DPV) at DNA modified glassy carbon fiber electrodes (GCFE). The decrease in guanine oxidation peak current at +0.9 V was used as an indicator for interaction mechanism in acetate buffer (pH 4.5). The studied drug-DNA interaction mechanism at charged electrode surface is similar to the in-vivo DNA-drug complex formation, where DNA is in close contact with charged phospholipid membranes and proteins. Thus, the fabricated biosensor helps in understanding the in-vivo mechanism of action of this anticancer drug.
 
Date 2009-01-28T05:44:44Z
2009-01-28T05:44:44Z
2008-11
 
Type Article
 
Identifier 0971–457X
http://hdl.handle.net/123456789/2865
 
Language en_US
 
Publisher CSIR
 
Source IJCT Vol.15(6) [November 2008]