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Changes in erythrocyte aggregation and deformability in diabetes mellitus: A brief review

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Title Changes in erythrocyte aggregation and deformability in diabetes mellitus: A brief review
 
Creator Singh, Megha
Shin, Sehyun
 
Subject Deformability
Diabetes mellitus
Erythrocyte aggregation
Techniques
 
Description 7-15
Diabetes mellitus (DM) is a metabolic disorder characterized by varying or persistent hyperglycemia either due to insufficient production of insulin by pancreas or improper utilization of the glucose. Erythrocytes remain in hyperglycemic environment throughout their life span and thus are subjected to series of compositional changes, which in turn affect their flow properties through alteration of deformation at individual level and aggregation at collective level. This brief review summarizes the changes in biochemical parameters primarily contributing to the erythrocyte deformability and aggregation as measured by various techniques, of blood samples obtained from diabetic subjects. The significant changes in erythrocyte aggregation and deformability, in comparison with that of control subjects show the relevance of these measurements. These changes are further supported by in vivo observations of blood flow through microvessels. Finally the relevance of these in combination with other clinical parameters is suggested.
 
Date 2009-01-28T11:28:45Z
2009-01-28T11:28:45Z
2009-01
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/2894
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(1) [January 2009]