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Evaluation of wound healing activity of extracts of plantain banana (Musa sapientum var. paradisiaca) in rats

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Title Evaluation of wound healing activity of extracts of plantain banana (Musa sapientum var. paradisiaca) in rats
 
Creator Agarwal, P K
Singh, A
Gaurav, K
Goel, Shalini
Khanna, H D
Goel, R K
 
Subject Antioxidant
Free radicals
Musa sapientum
Wound healing
 
Description 32-40
Plantain banana (M. sapientum var. paradisiaca, MS) has been shown to possess ulcer healing activity. The present work with plantain banana was undertaken with the premise that the drug promoting ulcer healing could have effect on wound healing also. Wound healing activity of MS was studied in terms of (i) percent wound contraction, epithelization period and scar area; (ii) wound breaking strength and (iii) on granulation tissue antioxidant status [estimation of superoxide dismutase (SOD) and reduced glutathione (GSH), free radical (lipid peroxidation, an indicator of tissue damage) and connective tissue formation and maturation (hexuronic acid, hydroxyproline and hexosamine levels)] in excision, incision and dead space wound models respectively. The rats were given graded doses (50-200 mg/kg/day) of aqueous (MSW) and methanolic (MSE) extracts of MS orally for a period of 10-21 days depending upon the type of study. Both extracts
(100 mg/kg) when studied for incision and dead space wounds parameters, increased wound breaking strength and levels of hydroxyproline, hexuronic acid, hexosamine, superoxide dismutase, reduced glutathione in the granulation tissue and decreased percentage of wound area, scar area and lipid peroxidation when compared with the control group. Both the extracts showed good safety profile. Plantain banana thus, favoured wound healing which could be due to its antioxidant effect and on various wound healing biochemical parameters.
 
Date 2009-01-28T11:12:44Z
2009-01-28T11:12:44Z
2009-01
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/2890
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(1) [January 2009]