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Effect of probenecid on kinetics of enrofloxacin in lactating goats after subcutaneous administration

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Title Effect of probenecid on kinetics of enrofloxacin in lactating goats after subcutaneous administration
 
Creator Narayan, Jai Prakash
Kumar, Nirbhay
Jha, H N
Jayachandran, C
 
Subject Enrofloxacin
Kinetics
Lactating goats
Probenecid
 
Description 53-56
A comparative pharmacokinetic study of enrofloxacin (5 mg/kg, sc) was conducted in probenecid-pretreated (70 mg/kg, orally 1.5 h prior to enrofloxacin administration) lactating goats to assess the effect of probenecid on the kinetics of enrofloxacin. Concentration of enrofloxacin in plasma, milk and urine was estimated by microbiological assay using Escherichia coli (ATCC 25922). Minimum detection level of enrofloxacin was 0.01 μg/ml. The plasma log concentration versus time curve showed monophasic pattern and followed one compartment open model. Plasma drug concentration was significantly higher during 1-2 h in probenecid-pretreated group. Significantly higher drug concentration in milk was noted at most of the time points, while significantly lower urine drug concentration (0.083-1 h and 5-12 h) were obtained in probenecid-pretreated group. The kinetic parameters (A, B and β) were significantly higher, while t₁/₂β, MRT and Vdarea were significantly lower in probenecid-pretreated group. Probenecid pretreatment decreased the urinary excretion of enrofloxacin, whereas enhanced excretion in milk which could be useful in cases of affections of udder in goats.
 
Date 2009-01-28T11:28:21Z
2009-01-28T11:28:21Z
2009-01
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/2893
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(1) [January 2009]