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Production of peptide antifungal antibiotic and biocontrol activity of Bacillus subtilis

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Title Production of peptide antifungal antibiotic and biocontrol activity of Bacillus subtilis
 
Creator Kumar, Ajay
Saini, Pragati
Shrivastava, J N
 
Subject Antifungal activity
Bacillus subtilis
Dermatophytes
Optimization
Peptide antibiotic.
 
Description 57-62
Among different bacterial cultures, a potent Bacillus subtilis MTCC-8114 was isolated from garden soil samples which showed 16 and 14 mm inhibition zones by spot inoculation method and 24 and 22 mm inhibition zones by well agar diffusion method against test fungi i.e. Microsporum fulvum and Trichophyton species. Among four media tested, the maximum growth and antibiotic production was found in trypticase soya broth (TSB) medium at 37º C, pH-7 and 48 h of incubation. The Rf value (0.64) by Thin Layer Chromatography (TLC) technique and UV and FTIR spectral data of the active antifungal compound, indicated that the isolated compound belongs to peptide antifungal antibiotic group. MIC value of antifungal antibiotic was 135 and 145 μg/ml.
 
Date 2009-01-28T11:29:00Z
2009-01-28T11:29:00Z
2009-01
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/2895
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(1) [January 2009]