Synthesis and in vitro study of biological activity of heterocyclic N-Mannich bases
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Title |
Synthesis and in vitro study of biological activity of heterocyclic N-Mannich bases
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Creator |
Shah, T B
Gupte, A Patel, M R Chaudhari, V S Patel, H Patel, V C |
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Subject |
Biginelli reaction
dihydropyrimidones N-Mannich bases antimicrobial activity |
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Description |
88-96
Three series of N-Mannich bases of 3,4-dihydropyrimidine-2(1H)-ones(DHPMs) 7a-g, 8a-g, and 9a-g have been prepared by Mannich reaction of DHPMs 4a-c with seven different heterocyclic secondary amino compounds 6a-g and formaldehyde 5. The precursors DHPMs 4a-c have been derived by a Biginelli reaction of three aromatic aldehydes 1a-c with ethylacetoacetate 2 and urea 3. The chemical structure of all the three series of N-Mannich bases have been elucidated by elemental analysis and spectral studies (IR, ¹H and ¹³C NMR). They have been assayed in vitro for their biological activity against E. coli and B. subtilis bacterial species and A. niger and C. albicans fungal microorganisms. |
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Date |
2009-01-30T11:32:38Z
2009-01-30T11:32:38Z 2009-01 |
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Type |
Article
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Identifier |
0376-4699
http://hdl.handle.net/123456789/2941 |
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Language |
en_US
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Publisher |
CSIR
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Source |
IJCB Vol.48B(1) [January 2009]
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