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Synthesis and in vitro study of biological activity of heterocyclic N-Mannich bases

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Title Synthesis and in vitro study of biological activity of heterocyclic N-Mannich bases
 
Creator Shah, T B
Gupte, A
Patel, M R
Chaudhari, V S
Patel, H
Patel, V C
 
Subject Biginelli reaction
dihydropyrimidones
N-Mannich bases
antimicrobial activity
 
Description 88-96
Three series of N-Mannich bases of 3,4-dihydropyrimidine-2(1H)-ones(DHPMs) 7a-g, 8a-g, and 9a-g have been prepared by Mannich reaction of DHPMs 4a-c with seven different heterocyclic secondary amino compounds 6a-g and formaldehyde 5. The precursors DHPMs 4a-c have been derived by a Biginelli reaction of three aromatic aldehydes 1a-c with ethylacetoacetate 2 and urea 3. The chemical structure of all the three series of N-Mannich bases have been elucidated by elemental analysis and spectral studies (IR, ¹H and ¹³C NMR). They have been assayed in vitro for their biological activity against E. coli and B. subtilis bacterial species and A. niger and C. albicans fungal microorganisms.
 
Date 2009-01-30T11:32:38Z
2009-01-30T11:32:38Z
2009-01
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/2941
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.48B(1) [January 2009]