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Synthesis and antimicrobial screening of 5-benzylidine-2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one and its derivatives

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Title Synthesis and antimicrobial screening of 5-benzylidine-2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one and its derivatives
 
Creator Mulwad, Vinata V
Mir, Abid Ali
Parmar, Hitesh T
 
Subject Aminocoumarin
Iminothiazolidinone
4-thiazolidin-one
Aromatic aldehydes
Antimicrobial activity
 
Description 137-141
2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one
4a-c have been synthesized from 6-amino-coumarin as starting material. Condensation of iminothiazolidinone with different substituted aromatic aldehydes occurred at reactive methylene group present at C-5 position of thiazolidin-4-one ring and resulted in the formation of 5-arylidene-2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one 5a-i. The formation of 2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one 4c was confirmed by hydrolysis with 2% HCl to give 3-(2-oxo-2H-benzopyran-6-yl)-thiazolidine-2,4-dione 6c. The structures of the compounds 2a-c, 4a-c, 5a-i and 6c have been established on the basis of spectral and analytical data. The compounds 5a-i has been screened for their antimicrobial activity and has been found to exhibit significant antibacterial activities.
 
Date 2009-01-30T11:25:09Z
2009-01-30T11:25:09Z
2009-01
 
Type Article
 
Identifier 0376-4699
http://hdl.handle.net/123456789/2933
 
Language en_US
 
Publisher CSIR
 
Source IJCB Vol.48B(1) [January 2009]