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Probable mechanism(s) of antifungal activity of HA-2-91—A tetraene antibiotic

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Title Probable mechanism(s) of antifungal activity of HA-2-91—A tetraene antibiotic
 
Creator Naik, S R
Gupte, T E
 
Subject Antifungal action
Affinity for sterols
Reversible binding process
Tetraene.
 
Description 91-96
HA-2-91 (a tetraene antibiotic) is produced by Streptomyces arenae var. ukrainiana and shown to elicit antifungal activity (in vitro) against yeasts and filamentous fungi including plant pathogens and clinical isolates. Experimental studies were carried out by using both biological as well as chemical methods to understand the probable mechanism(s) of antifungal action of HA-2-91. Experimental findings suggest that HA-2-91 binds to both ergosterol and cholesterol present on the fungal and mammalian cell membranes. However, results showed preferential binding of HA-2-91 towards ergosterol than cholesterol. Further, the interactions (bindings of HA-2-91 with membrane sterols) seem to be reversible process. With such preferential degree of binding of HA-2-91, the effect will be greater on fungal cell membrane than mammalian cell membrane. Hence, adverse reactions like haemolysis may not occur.
 
Date 2009-02-04T07:21:39Z
2009-02-04T07:21:39Z
2009-01
 
Type Article
 
Identifier 0972-5849
http://hdl.handle.net/123456789/2959
 
Language en_US
 
Publisher CSIR
 
Source IJBT Vol.8(1) [January 2009]