Record Details

Human granulocyte-macrophage colony-stimulating factor : The protein and its current & emerging applications

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Human granulocyte-macrophage colony-stimulating factor : The protein and its current & emerging applications
 
Creator Ghosh, Prasanta K
Bhardwaj, Devesh
Karnik, Rucha
 
Subject GM-CSF
cytokines
T-cell induction
cytokines applications
GM-CSF applications
Crohn’s disease
 
Description 435-448
Blood cells under a variety of conditions produce cytokines which regulate their proliferation, communication and functioning. The granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor mainly responsible for the proliferation of granulocyte-s and macrophages. It is a molecule of immense therapeutic interest due to its wide-ranging actions on immune cells. Recombinant human GM-CSF has been expressed, purified and characterized. It has diverse biological manifestations, which has led to its being explored for use in cancer therapy, AIDS therapy, as a vaccine adjuvant, in certain types of wound healing, promotion of collateral growth of coronary artery, usefulness in treating Crohn’s disease symptoms and in the management of a host of viral, bacterial and fungal infections. Newer therapeutic applications are also being unveiled. The physico-chemical as well as the biological features and the applications (current and emerging) of GM-CSF are discussed.
 
Date 2009-02-11T09:50:18Z
2009-02-11T09:50:18Z
2007-10
 
Type Article
 
Identifier 0972-5849
http://hdl.handle.net/123456789/3080
 
Language en_US
 
Relation Int. Cl.⁸ C12N15/09, 15/10, 15/11
 
Publisher CSIR
 
Source IJBT Vol.6(4) [October 2007]