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Celecoxib administration exhibits tissue specific effect on ³H-benzo(a)pyrene-DNA adduct formation in cigarette smoke inhaling mice

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Title Celecoxib administration exhibits tissue specific effect on ³H-benzo(a)pyrene-DNA adduct formation in cigarette smoke inhaling mice
 
Creator Koul, Ashwani
Tanwar, Lalita
Arora, Neha
 
Subject Carcinogen-DNA adduct
Carcinogenesis
Celecoxib
Cigarette smoke
Hepatic
Inhalation
Pulmonary
 
Description 83-90
In the present study, cigarette smoke (CS) exposure significantly enhanced ³H-B(a)P-DNA adduct formation in both the pulmonary and hepatic tissues. Mice co-treated with CS and celecoxib (a specific COX-2 inhibitor) exhibited a significant decrease in hepatic carcinogen-DNA adduct formation in comparison to the smoke exposed group, however the lungs of the co-treated animals exhibited a significant increase in carcinogen-DNA adduct formation when compared to the control group and smoke exposed group. CS exposure enhanced the activity of carcinogen activation enzymes in both the tissues and decreased the activity of carcinogen detoxification enzymes in the hepatic tissue only, when compared to the control group. Celecoxib administration to CS inhaling mice modulated the carcinogen biotransformation considerably when compared to the CS exposed group. Celecoxib administration to CS inhaling mice produced a low index of carcinogenesis in the hepatic tissue but increased the index of carcinogenesis in the pulmonary tissue. These observations seem to be critical and tissue specific when related to carcinogenesis.
 
Date 2009-02-11T07:10:47Z
2009-02-11T07:10:47Z
2009-01
 
Type Article
 
Identifier 0971-5544
http://hdl.handle.net/123456789/3065
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(2) [February 2009]