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Beneficial effects of modified egg* on oxidative stress in F₁- generation of metabolic syndrome-X induced Wistar rat

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Title Beneficial effects of modified egg* on oxidative stress in F₁- generation of metabolic syndrome-X induced Wistar rat
 
Creator Taneja, Satish Kumar
Singh, Kshetrimatyum Birla
 
Subject Cu
Diabetes mellitus
Omega-3 fatty acids
Mg
Mn
Modified egg
Oxidative stress
Vitamin- E
Zn
 
Description 104-112
Congenital malformations of neonates are one of the adverse effects of diabetic pregnancy which can be prevented by supplementation of vitamin E and C. The survived neonates usually are at higher risk to diabetes, hypertension, dyslipidemia and cardiovascular diseases that may possibly be prevented through antioxidants administration. In view of this information, the efficacy of modified poultry egg enriched with optimum minerals, vitamin E and omega-3 fatty acids was studied on F₁-generation, which were made to survive by feeding them this modified egg to diabetic mothers of Wistar rats. The survived F₁-generation displayed hyperglycemia, dyslipidemia and hypertension like their parents, evaluated after three months of the experiment. Their mineral status revealed a higher Zn and lower Cu, Mg and Mn levels in liver and kidney. Their lipid peroxidation products were however higher and the enzyme activities of superoxide dismutase, catalase, glutathione-
S-transferase, glutathione reductase, glutathione (reduced) and glucose -6 phosphate dehydrogenase were significantly lower. In the other group of F₁-generation, fed modified egg mixed diet, a significant reduction in the blood pressure, serum glucose, serum lipid profile, and the lipid peroxidation products, and a significant increase in the activities of enzymes per se with reversal of Zn, Cu, Mg and Mn levels closer to the control group were recorded. The data suggest that the modified egg can ameliorate the oxidative stress in F₁- generation of diabetic rats by improving the mineral status in their body.
 
Date 2009-02-11T07:27:56Z
2009-02-11T07:27:56Z
2009-02
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/3070
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(2) [February 2009]