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Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action

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Title Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action
 
Creator Preethi, Korengath Chandran
Kuttan, Girija
Kuttan, Ramadasan
 
Subject Anti-inflammatory agents
Calendula officinalis
Cyclooxygenase-2
Proinflammatory cytokines
 
Description 113-120
Calendula officinalis flower extract possessed significant anti-inflammatory activity against carrageenan and dextran-induced acute paw edema. Oral administration of 250 and 500 mg/kg body weight Calendula extract produced significant inhibition (50.6 and 65.9% respectively) in paw edema of animals induced by carrageenan and 41.9 and 42.4% respectively with inflammation produced by dextran. In chronic anti-inflammatory model using formalin, administration of 250 and 500 mg/kg body weight Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls. TNF-α production by macrophage culture treated with lipopolysaccharide (LPS) was found to be significantly inhibited by Calendula extract. Moreover, increased levels of proinflammatory cytokines IL-1β, IL-6, TNF-⍺ and IFN-ϒ and acute phase protein, C- reactive protein (CRP) in mice produced by LPS injection were inhibited significantly by the extract. LPS induced cyclooxygenase-2 (Cox-2) levels in mice spleen were also found to be inhibited by extract treatment. The results showed that potent anti-inflammatory response of C. officinalis extract may be mediated by the inhibition of proinflammatory cytokines and Cox-2 and subsequent prostaglandin synthesis.
 
Date 2009-02-11T07:29:14Z
2009-02-11T07:29:14Z
2009-01
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/3072
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(2) [February 2009]