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Development of pharmacophoric model of condensed pyridine and pyrimidine analogs as hydroxymethyl glutaryl coenzyme A reductase inhibitors
NOPR - NISCAIR Online Periodicals Repository
View Archive Info| Field | Value | |
| Title |
Development of pharmacophoric model of condensed pyridine and pyrimidine analogs as hydroxymethyl glutaryl coenzyme A reductase inhibitors
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| Creator |
Saxena, M
Soni, Love K Gupta, Arun K Wakode, S R Saxena, A K Kaskhedikar, S G |
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| Subject |
Pharmacophore
3D-QSAR Condensed pyridine and pyrimidine analogs HMG-CoA reductase inhibitors Anti- hyperlipidemic agents |
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| Description |
32-36
Quantitative structure-activity relationship (QSAR) has been established on a series of thirty-eight compounds of four different sets of condensed pyridine and pyrimidine analogs, for their hydroxymethyl glutaryl coenzyme (HMG-CoA) reductase inhibitor activity, in order to understand the essential structural requirement for binding with receptor, in terms of common biophoric and secondary sites employing APEX-3D software. Among several 3D pharmacophoric models with different sizes and arrangements, one model was selected based on r² = 0.8, chance |
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| Date |
2009-02-24T05:03:32Z
2009-02-24T05:03:32Z 2006-02 |
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| Type |
Article
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| Identifier |
0301-1208
http://hdl.handle.net/123456789/3259 |
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| Language |
en_US
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| Relation |
C12N9/99
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| Publisher |
CSIR
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| Source |
IJBB Vol.43(1) [February 2006]
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