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Nitric oxide levels during erythroid differentiation in K562 cell line

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Title Nitric oxide levels during erythroid differentiation in K562 cell line
 
Creator Küçükkaya, B
Öztürk, G
Yalçıntepe, L
 
Subject Nitric oxide
Erythroid differentiation
Hemin
K562 cell line
 
Description 251-253
Nitric oxide (NO) is endogenous mediator of numerous physiological processes that range from regulation of cardiovascular function and neurotransmission to antipathogenic and tumoricidal responses. This study was designed to investigate the possible role of NO during erythroid differentiation in K562 erythroleukemia cells. The chronic myelogenous leukemia (K562) cell line can be triggered in culture to differentiate along the erythrocytic pathway, in response to a variety of stimulatory agents. In this study, K562 cells were induced to synthesize hemoglobin by hemin. We investigated NOx (nitrate+nitrite) levels in uninduced (control) and hemin-induced K562 cell lysates during erythroid differentiation. Our results showed that NO levels decreased significantly on fourth and sixth day both in hemin-induced and control cells; the decrease was, however, more in hemin-induced group than in control group.
 
Date 2009-02-27T06:00:52Z
2009-02-27T06:00:52Z
2006-08
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3287
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.43(4) [August 2006]