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Hepato and reno protective action of Calendula officinalis L. flower extract

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Title Hepato and reno protective action of Calendula officinalis L. flower extract
 
Creator Preethi, Korengath Chandran
Kuttan, Ramadasan
 
Subject Antioxidant
Calendula officinalis
CCl₄,
Cisplatin
Hepatoprotection
Nephroprotection
 
Description 163-168
Flower extract of C. officinalis L. was evaluated for its protective effect against CCl₄ induced acute hepatotoxicity and cisplatin induced nephrotoxicity. The activities of serum marker enzymes of liver injury like glutamate pyruvate transaminase (SGPT), glutamate oxaloacetate transaminase (SGOT) and alkaline phosphatase (ALP) which were increased by CCl₄ injection was found to be significantly reduced by the pretreatment of the flower extract at 100 and 250 mg/kg body weight. The lipid peroxidation in liver, the marker of membrane damage and the total bilirubin content in serum were also found to be at significantly low level in the extract pretreated group, indicating its protective role. The kidney function markers like urea and creatinine were significantly increased in cisplatin treated animals. However, their levels were found to be lowered in the extract pretreated groups (100 and 250 mg/kg body weight). Moreover, cisplatin induced myelosuppression was ameliorated by the extract pretreatment. Treatment with the extract produced enhancement of antioxidant enzymes — superoxide dismutase and catalase and glutathione. Results suggest a protective role of the flower extract of C. officinalis against CCl₄ induced acute hepatotoxicity and cisplatin induced nephrotoxicity. Extract has been found to contain several carotenoids of which lutein, zeaxanthin and lycopene predominates. Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals.
 
Date 2009-02-27T07:18:36Z
2009-02-27T07:18:36Z
2009-03
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/3293
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(3) [March 2009]