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Effect of conventional antihypertensive drugs on hypolipidemic action of garlic in rats

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Title Effect of conventional antihypertensive drugs on hypolipidemic action of garlic in rats
 
Creator Asdaq, Syed Mohammed Basheeruddin
Inamdar, Mohammed Naseeruddin
Asad, Mohammed
 
Subject Captopril
Garlic homogenate
Hydrochlorothiazide
Lipid profile
Propranolol.
 
Description 176-181
The present study was undertaken to determine the possible alteration in hypolipidemic actions of garlic homogenate (GH) in presence of conventional antihypertensive drugs, propranolol (PRO), hydrochlorothiazide (HYD) and captopril (CAP). Albino rats fed with normal fat diet (NFD) or high fat diet (HFD) were treated with GH at three different doses (125, 250 and 500 mg/kg) orally for 30 days or in combination with PRO (10 mg/kg, po), HYD (10 mg/kg, po) and CAP (30 mg/kg, po) during last 7 days of GH treatment. After the treatment, total cholesterol (TC), LDL-cholesterol, triglyceride (TG) and HDL-cholesterol were measured in serum and antiatherogenic index was calculated. The result showed that moderate and high doses of GH possessed potential antiatherosclerotic property that was significantly attenuated by PRO and HYD. However, GH antihyperlipidemic activity was augmented by CAP. It was concluded that administration of PRO and HYD decrease the hypolipidemic effect of GH and administration of GH along with CAP augmented the hypolipidemic effect of GH in rats.
 
Date 2009-02-27T07:56:45Z
2009-02-27T07:56:45Z
2009-03
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/3299
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(3) [March 2009]