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Protective effect of Piper longum Linn. on monosodium glutamate induced oxidative stress in rats

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Title Protective effect of Piper longum Linn. on monosodium glutamate induced oxidative stress in rats
 
Creator Thomas, Mariyamma
Sujatha, K S
George, Sisilamma
 
Subject Monosodium glutamate
Piper longum
Rats
Toxicity
 
Description 186-192
Protective effect of ethanol extract of Piper longum Linn. against monosodium glutamate (MSG) induced toxicity was studied. Rats, orally administered with MSG at a dose of 8 mg/g body weight for 20 consecutive days, showed an increase in liver weight and rate of lipid peroxidation. Glutathione (GSH) in serum, liver and kidney showed decreased concentration. Significant increase was noticed in activities of serum alanine amino transferase (ALT) and aspartate amino transferase (AST), levels of serum triacylglycerol, total cholesterol and urea. Histopathological examination of liver and kidney showed central venous congestion, diffuse degeneration and necrosis of hepatocytes in para cortical and midzonal areas of liver and diffuse cortical tubular degeneration of kidney. Oral administration of ethanol extract of P. longum fruits at 300 mg/kg body weight along with MSG significantly reduced the levels of lipid peroxides in serum, liver and kidney, serum AST activity, serum levels of triacylglycerol and total cholesterol. Though, there was an increase in the level of GSH in tissues it was not significant. However, the treatment failed to reduce the levels of ALT and urea. Examination of tissue sections also exhibited normal histological architecture of both the organs. The present study revealed that administration of P. longum provided significant protection to liver and kidney from the oxidative stress of MSG, though the dose rate was not sufficient to provide a complete protection.
 
Date 2009-02-27T07:57:05Z
2009-02-27T07:57:05Z
2009-03
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/3300
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(3) [March 2009]