Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain
NOPR - NISCAIR Online Periodicals Repository
View Archive InfoField | Value | |
Title |
Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain
|
|
Creator |
Kuhad, Anurag
Bishnoi, Mahendra Chopra, Kanwaljit |
|
Subject |
Adenosine
Diabetes Duloxetine Neuropathy |
|
Description |
193-197
The involvement of adenosinergic pathway in the anti-nociceptive effect of duloxetine, a balanced 5-HT/NE reuptake inhibitor, was evaluated in streptozotocin induced diabetic male albino mice of Laca strain. After four weeks of single injection of streptozotocin (200 mg/kg, ip), mice were tested in the tail immersion and hot-plate assays. Cerebral adenosine levels were measured by high-performance liquid chromatography (HPLC/PDA detector). Diabetic mice exhibited significant hyperalgesia along with increased plasma glucose, decreased body weights and reduced cerebral adenosine levels. Administration of duloxetine (5, 10 and 20 mg/kg, ip) to diabetic mice produced dose-dependent anti-nociceptive effect in both tail-immersion and hot-plate assays. Adenosine levels were also significantly and dose-dependently increased by different doses of duloxetine. The results demonstrated the involvement of adenosinergic pathway in duloxetine mediated anti-hyperalgesia in diabetic neuropathic pain. |
|
Date |
2009-02-27T07:21:12Z
2009-02-27T07:21:12Z 2009-03 |
|
Type |
Article
|
|
Identifier |
0019-5189
http://hdl.handle.net/123456789/3295 |
|
Language |
en_US
|
|
Publisher |
CSIR
|
|
Source |
IJEB Vol.47(3) [March 2009]
|
|