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Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain

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Title Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain
 
Creator Kuhad, Anurag
Bishnoi, Mahendra
Chopra, Kanwaljit
 
Subject Adenosine
Diabetes
Duloxetine
Neuropathy
 
Description 193-197
The involvement of adenosinergic pathway in the anti-nociceptive effect of duloxetine, a balanced 5-HT/NE reuptake inhibitor, was evaluated in streptozotocin induced diabetic male albino mice of Laca strain. After four weeks of single injection of streptozotocin (200 mg/kg, ip), mice were tested in the tail immersion and hot-plate assays. Cerebral adenosine levels were measured by high-performance liquid chromatography (HPLC/PDA detector). Diabetic mice exhibited significant hyperalgesia along with increased plasma glucose, decreased body weights and reduced cerebral adenosine levels. Administration of duloxetine (5, 10 and 20 mg/kg, ip) to diabetic mice produced dose-dependent anti-nociceptive effect in both tail-immersion and hot-plate assays. Adenosine levels were also significantly and dose-dependently increased by different doses of duloxetine. The results demonstrated the involvement of adenosinergic pathway in duloxetine mediated anti-hyperalgesia in diabetic neuropathic pain.
 
Date 2009-02-27T07:21:12Z
2009-02-27T07:21:12Z
2009-03
 
Type Article
 
Identifier 0019-5189
http://hdl.handle.net/123456789/3295
 
Language en_US
 
Publisher CSIR
 
Source IJEB Vol.47(3) [March 2009]