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Protective effect of liposomal formulation of tuftsin (a naturally occurring tetrapeptide) against cyclophosphamide-induced genotoxicity and oxidative stress in mice

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Title Protective effect of liposomal formulation of tuftsin (a naturally occurring tetrapeptide) against cyclophosphamide-induced genotoxicity and oxidative stress in mice
 
Creator Arif, K
Ejaj, A
Maroof, A
Azmat, A K
Arun, C
Fatima, N
Gatoo, M A
Owais, M
 
Subject Genotoxicity
Cyclophosphamide
Tuftsin
Liposome
Oxidative stress
 
Description 45-52
Tuftsin, a naturally occurring tetrapeptide with a sequence Thr-Lys-Pro-Arg was evaluated for its in vivo protective effect against cyclophosphamide-induced genotoxicity and oxidative stress in Swiss albino mice. The anticancer drug cyclophosphamide (CP) was administered intra-peritonially to induce mutagenic effect. The drug treatment caused significant increase in chromosomal aberrations, formation of micronucleated polychromatic erythrocytes (MNPCE’s), as well as oxidative stress and decrease in lipid peroxidation in liver of the animals. The pretreatment with tuftsin abolished such effects in dose-dependent manner and also increased mitotic index in the experimental animals. Results of the present study validated chemo-preventive properties of tuftsin against CP-induced chromosomal mutations and cellular injury of liver by oxidative stress.
 
Date 2009-03-05T06:27:56Z
2009-03-05T06:27:56Z
2009-02
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3335
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.46(1) [February 2009]