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Role of bilirubin as antioxidant in neonatal jaundice and effect of ethanolic extract of sweet lime peel on experimentally induced jaundice in rat

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Title Role of bilirubin as antioxidant in neonatal jaundice and effect of ethanolic extract of sweet lime peel on experimentally induced jaundice in rat
 
Creator Nag, N
Halder, S
Chaudhuri, R
Adhikary, S
Mazumder, S
 
Subject Bilirubin
Antioxidant
Neonatal jaundice
Oxidative stress
Phototherapy
Sweet lime peel
 
Description 73-78
Bilirubin above a threshold level is toxic to human system and is excreted in urinary and through gastrointestinal tract. The role of bilirubin as antioxidant is debatable. This paper aims at elucidating the role of bilirubin as an antioxidant in neonatal jaundice patients. It is observed that bilirubin up to 6 mg/dl in blood acts as an antioxidant and above 12.5 mg/dl is strongly prooxidant. Phototherapy is the accepted therapeutic management of neonatal jaundice and has been shown to enhance the oxidative stress. Approaches have been taken to formulate a herbal medication which will reduce bilirubin level in the neonates without inducing additional damages. The ethanolic extract of sweet lime peel, administered orally at a dose of 72 µg is found to reduce the oxidative stress in erythrocytes of phenylhydrazine-induced jaundiced rats treated with phototherapy.
 
Date 2009-03-05T06:28:58Z
2009-03-05T06:28:58Z
2009-02
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3337
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.46(1) [February 2009]