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Stress modulating antioxidant effect of Nardostachys jatamansi

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Title Stress modulating antioxidant effect of Nardostachys jatamansi
 
Creator Lyle, Nazmun
Bhattacharyya, Dipankar
Sur, Tapas K
Munshi, Santanu
Paul, Suhrita
Chatterjee, Suparna
Gomes, Antony
 
Subject Adaptogen
Corticosterone
Lipid peroxidation
Nardostachys jatamansi
Restraint stress
ROS
Ulcer
 
Description 93-98
The rhizomes of Nardostachys jatamansi, the plant commonly known as Jatamansi have been described in Ayurveda for their soothing and sedative action on the central nervous system. In the present study, the anti-stress effect of hydro-ethanolic extract (70%) of N. jatamansi (NJE) was evaluated in reference to its antioxidant property. Wistar rats were divided into four groups: naïve, stressed, and T-200 and T-500 stressed with oral pre-treatment of NJE 200 and 500 mg/kg, respectively. Restraint of rats in metallic chambers for 4 h at 4ºC was followed by sacrifice and assessment of stress-induced alterations in biochemical parameters, incidence and severity of ulcers. Lipid peroxidation (LPO) and NO levels in stomach and LPO, NO levels and catalase activity in brain, plasma corticosterone level and adrenal ascorbic acid were measured.
In vitro antioxidant activity of NJE was studied by measuring the free radical scavenging activity. NJE showed potent antioxidant activity and significantly reversed the stress-induced elevation of LPO and NO levels and decrease in catalase activity in the brain. It inhibited the incidence of gastric ulcerations and reversed the alterations in biochemical parameters/markers of stress-induced gastric ulceration. NJE also significantly altered stress-induced increase in adrenal and spleen weights and decrease in level of ascorbic acid in adrenal gland. Elevation of plasma corticosterone level was negated dose- dependently. The findings suggest that the NJE possesses significant anti-stress activity, which may be due to its antioxidant activity.
 
Date 2009-03-05T05:08:55Z
2009-03-05T05:08:55Z
2009-02
 
Type Article
 
Identifier 0301-1208
http://hdl.handle.net/123456789/3323
 
Language en_US
 
Publisher CSIR
 
Source IJBB Vol.46(1) [February 2009]